L-Thyroxine

Brand:whmoli

Description:Basic Info Product Name:L-Thyroxine Other Name:T4 Purity:98%min CAS No.:51-48-9 M.W.:776.87 M.F.:C15H11I4NO4 Assay:HPLC Melting Point:223ºC Water Solubility:Insoluble Appearance:White powder

Origin:China Hubei

Model:51-48-9

MOQ:10GramsGram/Grams

Port:Hong Kong,Shanghai,Shenzhen

Payment Terms:T/T

Supply Time:Day

Delivery Time:2017-09-20

Packaging Details:Suitable package according to your quantity

Product detail:Basic Info

Product Name	L-Thyroxine
Other Name	T4
Purity	98%min
CAS No.	51-48-9
M.W.	776.87
M.F.	C15H11I4NO4
Assay	HPLC
Melting Point	223ºC
Water Solubility	Insoluble
Appearance	White powder

Description:
L-thyroxine is a synthetic thyroid hormone that is chemically identical to thyroxine (T4),which is naturally secreted by the follicular cells of the thyroid gland.It is used to treat thyroid hormone deficiency,and occasionally to prevent the recurrence of thyroid cancer.Like its naturally secreted counterpart,levothyroxine is achiral compound in the L-form.The related drug dextrothyroxine (D-thyroxine) was used in the past as a treatment for hypercholesterolemia (elevated cholesterol levels) but was withdrawn due to cardiac side effects.It is on the World Health Organization's List of Essential Medicines,a list of the most important medication needed in a basic health system

Application:
L-thyroxine is typically used to treat hypothyroidism,and is the treatment of choice for patients with hypothyroidism,who often require lifelong thyroid hormone therapy.It may also be used to treat goiter via its ability to lower thyroid-stimulating hormone (TSH),a hormone that is considered goiter-inducing.L-thyroxine is also used as interventional therapy in patients with nodular thyroid disease or thyroid cancer to suppress thyroid-stimulating hormone (TSH) secretion.

Levothyroxine (T4) is a synthetically prepared levo isomer of thyroxine,the major hormone secreted from the thyroid gland.Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood.Thyroxine is peripherally deiodinated to form triiodothyronine (T3) which exerts a broad spectrum of stimulatory effects on cell metabolism.
 
Thyroid hormone increases the metabolic rate of cells of all tissues in the body.In the fetus and newborn,thyroid hormone is important for the growth and development of all tissues including bones and the brain.
 
In adults,thyroid hormone helps to maintain brain function, food metabolism,and body temperature, among other effects.The symptoms of thyroid deficiency relieved by levothyroxine include slow speech,lack of energy,weight gain,hair loss,dry thick skin and unusual sensitivity to cold.

COA

Product name	L-Thyroxine
Appearance	White crystalline powder
Assay(*)	98~101.0%	99.3%
Identification	By UV, To match with working standard	Complies
Related Substances	Not more than the reference solution (0.05%)	Complies
Heavy metals	≤10ppm	10ppm
Loss on drying	<0.5%	0.15%
Resiue on ignition	≤0.1%	0.05%
Melting	235°C	Complies

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