medicines and drugs Enrofloxacin Injection

COMPOSITION:

Contains per ml.:

Enrofloxacin…………... 50 mg.

Solvents ad………….... 1 ml.

Enrofloxacin…………... 100 mg.

Solvents ad………….... 1 ml.

DESCRIPTION:

It is a clear sterile light yellow solution for injection.

Mode of action:

Enrofloxacin deactivate DNA gyrase making the reading of DNA impossible. This results in death of the bacteria cell.

Mammalian DNA Gyrase is of a completely different shape and remains unchanged.

INDICATIONS:

Enrofloxacin is a synthetic, broad spectrum antimicrobial substance, belonging to the fluoroquinolone group of antibiotics. It is bactericidal in action and effective against many gram positive and gram negative bacteria and mycoplasmas.

Dogs and Cats

The product is indicated in the treatment of bacterial infections of the alimentary, respiratory and urogenital tracts, skin, secondary wound infections and otitis externa where clinical experience, supported where possible by sensitivity testing of the causal organism, indicates enrofloxacin as the drug of choice.

Cattle

Diseases of the respiratory and alimentary tract of bacterial or mycoplasmal origin (e.g. pasteurellosis, mycoplasmosis, coli-bacillosis, coli-septicaemia and salmonellosis) and secondary bacterial infections subsequent to viral conditions (e.g. viral pneumonia) where clinical experience, supported where possible by sensitivity testing of the causal organism, indicates enrofloxacin as the drug of choice.

Pigs

Diseases of the respiratory and alimentary tract of bacterial or mycoplasmal origin (e.g. pasteurellosis, actinobacillosis, mycoplasmosis, coli-bacillosis, coli-septicaemia and salmonellosis) and mulifactorial diseases such as atrophic rhinitis and enzootic pneumonia, where clinical experience, supported where possible by sensitivity testing of the causal organism, indicates enrofloxacin as the drug of choice.

DOSAGE AND ADMINISTRATION:

Dogs and Cats

1 ml product per 10 kg bodyweight (5 mg enrofloxacin per kg bodyweight) by subcutaneous injection once daily for up to 5 days. Treatment may be initiated with the injection and maintained orally with Flavour Tablets.

Cattle

0.5 ml per 10 kg bodyweight (2.5 mg enrofloxacin per kg bodyweight) daily by subcutaneous injection for 3 days. This rate may be doubled (1 ml per 10 kg; 5 mg/kg) for 5 days for salmonellosis and complicated respiratory disease. Not more than 10 ml should be administered at one subcutaneous injection site.

Pigs

0.5 ml per 10 kg bodyweight (2.5 mg enrofloxacin per kg bodyweight) daily by intramuscular injection for 3 days. This rate may be doubled (1 ml per 10 kg; 5 mg/kg) for 5 days for salmonellosis and complicated respiratory disease. Not more than 2.5 ml should be administered at one intramuscular injection site.

Use during pregnancy and lactation

There is no restriction on the use of this product during pregnancy and lactation.

CONTRAINDICATIONS

Should not be used for prophylaxis.

Not for use in cats less than 8 weeks of age.

Do not exceed the recommended dosage. In accidental overdose there is no antidote and treatment should be symptomatic.

Official and local antimicrobial policies should be taken into account when the product is used.

WITHDRAWAL TIMES:

MEAT

Cattle: Animals must not be slaughtered for human consumption during treatment. Animals may be slaughtered for human consumption only after 14 days from the last treatment.

Pigs: Animals must not be slaughtered for human consumption during treatment. Animals may be slaughtered for human consumption only after 10 days from the last treatment.

MILK

Not to be used in animals producing milk for human consumption.

User Safety: It is an alkaline solution. Wash any splashes from skin and eyes immediately with water.

Do not eat, drink or smoke whilst using the product.

Care should be taken to avoid accidental self-injection. If accidental injection occurs, seek medical advice immediately.

PHARMACEUTICAL PRECAUTIONS:

Do not store above 25°C.

Store in a dry place.

Following withdrawal of the first dose, use the product within 28 days. Discard unused material.

Unused product or waste material should be disposed of in accordance with national requirements.