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Basic Info
Application
Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body.Licensed in the United States under the brand name Fareston,toremifene citrate is FDA-approved for use in advanced (meta static) breast cancer.It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.
It has already been covered that Toremifene is a SERM,and serves to block Estrogen at various receptor sites in certain tissues within the body (breast tissue in particular). As a layman explanation,Toremifene pretends to be a 'fake' Estrogen that occupies Estrogen receptors within breast tissue.With these receptors occupied by Toremifene,real Estrogen cannot perform their jobs there.Toremifene does not reduce total blood plasma levels of Estrogen.In addition to being antagonistic to Estrogen receptors in breast tissue,it is also antagonistic to Estrogen at the hypothalamus gland (this essentially 'tricks' the hypothalamus into thinking there is little or no circulating Estrogen levels in the body,causing it to increase its manufacture of Testosterone so that it can utilize aromatization to restore these levels.
Effect
Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body.Licensed in the United States under the brand name Fareston,toremifene citrate is FDA-approved for use in advanced (meta static) breast cancer.It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.
Toremifene Citrate exerts its effects by antagonizing the estrogen receptor in some tissues,and agonizing it in others. In this way,certain estrogenic pathways are activated and others are blockaded.It seems to exert estrogenic effects on blood lipids,reducing LDL and total cholesterol,as well as estrogenic effects on bone,improving density.It would also appear to exert anti-estrogenic effects in breast tissue,displacing the traditional effects of estrogen,effectively helping prevent breast cancer in postmenopausal women.
COA
Other Anti-Estrogens&PCT Powders
Tamoxifen Citrate CAS 54965-24-1
Raloxifene Hydrochloride CAS 82640-04-8
Clomifene citrate(Clomid) CAS 50-41-9
M-esterolone(Proviron) CAS 1424-00-6
L-etrozole(Femara) CAS 112809-51-5
A-nastrozole(Arimidex) CAS 120511-73-1
E-xemestane(Aromasin) CAS 107868-30-4
F-ormestane(Lentaron) CAS 566-48-3
Toremifene Citrate CAS 89778-27-8
Finasteride(Proscar,Propecia) CAS 98319-26-7
Dutasteride(Avodart) CAS 164656-23-9
T-estolactone(Teslac) CAS 968-93-4
| Product Name | Toremifene citrate |
| CAS No. | 89778-27-8 |
| M.F. | C32H36ClNO8 |
| M.W. | 598.08 |
| Assay | 99% |
| Melting Point | 158-164ºC |
| Appearance | White powder |
Application
Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body.Licensed in the United States under the brand name Fareston,toremifene citrate is FDA-approved for use in advanced (
It has already been covered that Toremifene is a SERM,and serves to block Estrogen at various receptor sites in certain tissues within the body (breast tissue in particular). As a layman explanation,Toremifene pretends to be a 'fake' Estrogen that occupies Estrogen receptors within breast tissue.With these receptors occupied by Toremifene,real Estrogen cannot perform their jobs there.Toremifene does not reduce total blood plasma levels of Estrogen.In addition to being antagonistic to Estrogen receptors in breast tissue,it is also antagonistic to Estrogen at the hypothalamus gland (this essentially 'tricks' the hypothalamus into thinking there is little or no circulating Estrogen levels in the body,causing it to increase its manufacture of Testosterone so that it can utilize aromatization to restore these levels.
Effect
Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body.Licensed in the United States under the brand name Fareston,toremifene citrate is FDA-approved for use in advanced (
Toremifene Citrate exerts its effects by antagonizing the estrogen receptor in some tissues,and agonizing it in others. In this way,certain estrogenic pathways are activated and others are blockaded.It seems to exert estrogenic effects on blood lipids,reducing LDL and total cholesterol,as well as estrogenic effects on bone,improving density.It would also appear to exert anti-estrogenic effects in breast tissue,displacing the traditional effects of estrogen,effectively helping prevent breast cancer in postmenopausal women.
COA
| TEST ITEMS | SPECIFICATION | RESULTS |
| De |
White or Almost White Crystalline Powder | White Powder |
| Identification | Positive | Positive |
| Assay | 97.00~103.00% | 99.38% |
| Loss On Drying | 0.5%max | 0.25% |
| Melting Point | 95~99ºC | 96.0~98.0ºC |
| Specific Rotation | +48°~+51° | +49.0° |
| Organic Volatile Impurities | meets the requirments. | Conforms |
| Residual Solvents | meets the requirments. | Conforms |
| Conclusion | The specification conform with USP32 standard | |
Other Anti-Estrogens&PCT Powders
Tamoxifen Citrate CAS 54965-24-1
Raloxifene Hydrochloride CAS 82640-04-8
Clomifene citrate(Clomid) CAS 50-41-9
M-esterolone(Proviron) CAS 1424-00-6
L-etrozole(Femara) CAS 112809-51-5
A-nastrozole(Arimidex) CAS 120511-73-1
E-xemestane(Aromasin) CAS 107868-30-4
F-ormestane(Lentaron) CAS 566-48-3
Toremifene Citrate CAS 89778-27-8
Finasteride(Proscar,Propecia) CAS 98319-26-7
Dutasteride(Avodart) CAS 164656-23-9
T-estolactone(Teslac) CAS 968-93-4
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